Transcriptomic analysis of the innate immune signatures of a SARS-CoV-2 protein subunit vaccine ZF2001 and an mRNA vaccine RRVSARS-CoV-2 단백질 소단위 백신 ZF2001 및 mRNA 백신 RRV의 타고난 면역 특징의 전사체 분석Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, [키워드] Activation Analysis Anti-viral antibody approach binding CD74 Cell comparable COVID-19 cytokine Cytokines early response elicited expression level expression of gene framework Gene Expression Genes immune response immune responses immunization innate immune innate immune response Innate immunity involved mapped MHC class mRNA mRNA vaccine neutralization Neutralization antibody Pattern recognition pattern recognition receptor Pattern recognition receptors post vaccination Protein subunit protein subunit vaccine PRRs RNA degradation robust SARS-CoV-2 SARS-CoV-2 protein subunit Subunit vaccine Tap1 titre titres Transcription transcriptional Transcriptome transcriptome sequencing Transcriptome sequencing. transcriptomic transduction Vaccine ZF2001 [DOI] 10.1080/22221751.2022.2059404 PMC 바로가기 [Article Type] Article
Omicron (B.1.1.529) – A new heavily mutated variant: Mapped location and probable properties of its mutations with an emphasis on S-glycoproteinArticle Published on 2022-10-312022-11-16 Journal: International journal of biological macromolecules [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 receptor addition Analysis analyzed antibodies antibody Antibody binding B.1.1.529 bioinformatics characterized contribute country D614G eight human ACE2 receptor information investigated K417N mapped molecular mutated Mutation mutations N501Y NAb nAb escape. omicron outcome performed Quotient RBD RBD mutation recorded Region reported Research S477N SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 VoC Seven spike spike mutation Spread statistical the binding affinity the RBD the SARS-CoV-2 variant while ΔΔG [DOI] 10.1016/j.ijbiomac.2022.07.254 PMC 바로가기
SARS-CoV-2 variants of concern and spike protein mutational dynamics in a Swedish cohort during 2021, studied by Nanopore sequencingArticle Published on 2022-10-182022-11-15 Journal: Virology Journal [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] A222V analysed approach ARTIC Network assist bioinformatics can be used circulating variant Cohort COVID-19 COVID-19 pandemic Delta delta variant distribution genomic Health include less mapped Mutation mutations nanopore sequencing National occurred omicron Patient positive primer Protein public health public health measures Q677H S protein SARS-CoV-2 SARS-CoV-2 genomes SARS-CoV-2 variant sequence Sequencing sequencing method spike Spike protein Surveillance Swedish the S protein the SARS-CoV-2 the Spike Uppsala County variant variants variants of concern. variants of interest VoC whole-genome sequencing [DOI] 10.1186/s12985-022-01896-x PMC 바로가기
COVID-19 prevalence and infection control measures at homeless shelters and hostels in high-income countries: a scoping reviewArticle Published on 2022-10-152022-11-16 Journal: Systematic Reviews [Category] 변종, [키워드] absence Analysis applied assessment Asymptomatic conducted country COVID-19 COVID-19 outbreak COVID-19 pandemic Critical database demographics disease events Evidence exclusion Factor global health Health Homeless population Homeless shelters impacted implementation infection control limitation mapped measure Measures offer outbreak outcome people experiencing homelessness populations portal Prevalence prevalence of COVID-19 prevention protocol public health Registered Research screened Shelter workers. Spread the WHO university variant York [DOI] 10.1186/s13643-022-02089-x PMC 바로가기
Detection of SARS-CoV-2 in a dog with hemorrhagic diarrheaArticle Published on 2022-10-122022-11-15 Journal: BMC veterinary research [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] acute respiratory syndrome Affect African amino acid substitution analyzed Asymptomatic B.1.177 Bacterial Cell Ceuta characteristic circulation coronavirus COVID-19 detection diarrhea disease dog Dog COVID-19 excluded fecal gastrointestinal tract Genome Hemorrhagic Highland human SARS-CoV-2 human-to-animal transmission Ile402Val S protein substitution Infection Interaction intrinsic knowledge mapped microbial Microbiome MOST negative test Next-generation sequencing NGS North one health pandemic Pathogens pathology positive presenting RBD Receptor binding domain reported RT-PCR test S protein SARS-CoV-2 SARS-CoV-2 genome sequence Sequencing Spain Spanish suffered Terrier the S protein the spike protein USA variant viral loads viral variant virus West zoonosis. [DOI] 10.1186/s12917-022-03453-8 PMC 바로가기
Tissue-specific pathway activities: A retrospective analysis in COVID-19 patientsArticle Published on 2022-09-152022-11-16 Journal: Frontiers in Immunology [Category] SARS, 치료기술, [키워드] ACE2 receptor activity Affect affected Alter anticoagulation arachidonic acid calculated changed changes in cholesterol Coagulation complement COVID-19 COVID-19 patient COVID-19 patients example expressed highlight Inflammation less linolenic acid lung Map mapped mechanism metabolism molecular multiple tissues non-COVID-19 patient organ other tissue pathway pathway activity Pathways progression Protein proteomics data RAS regulatory pathway reported Retrospective analysis SARS-CoV-2 SARS-COV-2 infection spleen the disease thrombosis Thyroid tissue tissue-specific proteomics data. tissues virus WikiPathways Wilcoxon test [DOI] 10.3389/fimmu.2022.963357 PMC 바로가기
Structural- and Site-Specific N- Glycosylation Characterization of COVID-19 Virus Spike with StrucGPArticle Published on 2022-09-132022-11-15 Journal: Analytical Chemistry [Category] SARS, 치료기술, [키워드] addition Algorithm analyzed characterization COVID-19 COVID-19 virus glycan glycosylation Infection Mannose 6-phosphate mapped motif Previous studies previous study Protein residues SARS-CoV-2 Sequencing spike Structure structures Support the S protein trimer [DOI] 10.1021/acs.analchem.2c02265 PMC 바로가기
Mapping monoclonal anti-SARS-CoV-2 antibody repertoires against diverse coronavirus antigensArticle Published on 2022-09-022022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome anti-SARS-CoV-2 antibody antibody Antigen assist Betacoronavirus betacoronaviruses bioinformatic analysis convalescent coronavirus cross-reactive cross-reactive antibodies cross-reactive antibody diagnostics Donor donors Effectiveness fatality functional individual mapped mapping monoclonal natural human antibody neutralization potency Next-generation sequencing NGS non-specific Patient performed produced response SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants specificity tested the antibody Transmissibility unique Vaccines yeast yeast display. [DOI] 10.3389/fimmu.2022.977064 PMC 바로가기
Whole-genome sequencing of SARS-CoV-2 reveals diverse mutations in circulating Alpha and Delta variants during the first, second, and third waves of COVID-19 in South Kivu, east of the Democratic Republic of the CongoResearch article Published on 2022-09-012022-10-05 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] A.23.1 Analysis B.1.351 B.1.617.2 circulating circulation coding sequence consensus genome COVID-19 D614G Delta delta variant Diagnosis disease severity dominant Genes Genetic evolution Genetic variation genome coverage genomic global pandemic highlight identify include information isolate Lineage management mapped molecular MOST Mutation nucleocapsid protein objective ORF1ab ORF3 outbreak Oxford P.1 pandemic pangolin Phylogenetic analysis Point mutation processed reference genome responsible Result reveal SARS-CoV-2 SARS-CoV-2 isolate sequence sequenced Sequencing Seven South South Kivu subsequent Surveillance synonymous the SARS-CoV-2 genome Treatment variant variants were used whole-genome sequencing Wuhan [DOI] 10.1016/j.ijid.2022.05.041 [Article Type] Research article
An Examination of SARS-CoV-2 Transmission Based on Classroom Distancing in Schools With Other Preventive Measures in Place-Missouri, January-March 20212021년 1월-3월 미주리 주에서 다른 예방 조치가 있는 학교의 교실 거리를 기반으로 한 SARS-CoV-2 전파 조사Article Published on 2022-09-012022-09-11 Journal: Public health reports (Washington, D.C. : 1974) [Category] COVID19(2023년), SARS, 변종, [키워드] analyzed classroom close contact conducted Contact COVID-19 COVID-19 pandemic Delta delta variant evaluate evaluated event events examination GRADE K-12 mapped measure occurred Other people with COVID-19 physical physical distancing potential transmission Prevalence Prevention strategy Safe SARS-CoV-2 SARS-CoV-2 transmission School school health Schools students Support symptomatic tested Transmission variant Ventilation Ventilation. whole-genome sequencing widespread with COVID-19 [DOI] 10.1177/00333549221109003 PMC 바로가기 [Article Type] Article